The use of in-band full-duplex (FD) enables nodes to simultaneously transmit and receive on the same frequency band, which challenges the traditional assumption in wireless network design. The full-duplex capability enhances spectral efficiency and decreases latency, which are two key drivers pushing the performance expectations of next-generation mobile networks. In less than ten years, in-band FD has advanced from being demonstrated in research labs to being implemented in standards, presenting new opportunities to utilize its foundational concepts. Some of the most significant opportunities include using FD to enable wireless networks to sense the physical environment, integrate sensing and communication applications, develop integrated access and backhaul solutions, and work with smart signal propagation environments powered by reconfigurable intelligent surfaces. However, these new opportunities also come with new challenges for large-scale commercial deployment of FD technology, such as managing self-interference, combating cross-link interference in multi-cell networks, and coexistence of dynamic time division duplex, subband FD and FD networks.