This paper investigates the fundamental tradeoff between cache size and download time in the (H;r;M;N) combination network, where a server with N files is connected to H relays (without caches) and each of the K:=\binom{H}{r} users (with caches of size M files) is connected to a different subset of r relays. Existing schemes fall within two categories: either use the uncoded symmetric cache placement originally proposed for the shared-link model and design delivery phase dependent on the network topology, or effectively divide the combination network into H independent shared-link networks each serving \binom{H-1}{r-1} users; in either case, the placement phase is independent of network topology. In this paper, a novel strategy is proposed where the coded cache placement is dependent on network topology. The proposed scheme is shown to be information theoretically optimal for large cache size. In addition, when not exactly optimal, the proposed scheme can also outperform existing schemes.