Recently, the precise performance of the Generalized LASSO algorithm for recovering structured signals from compressed noisy measurements, obtained via i.i.d. Gaussian matrices, has been characterized. The analysis is based on a framework introduced by Stojnic and heavily relies on the use of Gordon's Gaussian min-max theorem (GMT), a comparison principle on Gaussian processes. As a result, corresponding characterizations for other ensembles of measurement matrices have not been developed. In this work, we analyze the corresponding performance of the ensemble of isotropically random orthogonal (i.r.o.) measurements. We consider the constrained version of the Generalized LASSO and derive a sharp characterization of its normalized squared error in the large-system limit. When compared to its Gaussian counterpart, our result analytically confirms the superiority in performance of the i.r.o. ensemble. Our second result, derives an asymptotic lower bound on the minimum conic singular values of i.r.o. matrices. This bound is larger than the corresponding bound on Gaussian matrices. To prove our results we express i.r.o. matrices in terms of Gaussians and show that, with some modifications, the GMT framework is still applicable.