With the exponential surge in traffic data and the pressing need for ultra-low latency in emerging intelligence applications, it is envisioned that 6G networks will demand disruptive communication technologies to foster ubiquitous intelligence and succinctness within the human society. Semantic communication, a novel paradigm, holds the promise of significantly curtailing communication overhead and latency by transmitting only task-relevant information. Despite numerous efforts in both theoretical frameworks and practical implementations of semantic communications, a substantial theory-practice gap complicates the theoretical analysis and interpretation, particularly when employing black-box machine learning techniques. This article initially delves into information-theoretic metrics such as semantic entropy, semantic distortions, and semantic communication rate to characterize the information flow in semantic communications. Subsequently, it provides a guideline for implementing semantic communications to ensure both theoretical interpretability and communication effectiveness.