We show that the third-order negativity provides a necessary and sufficient criterion for full separability of tripartite pure states, and extend this to mixed states beyond bipartite diagnostics such as negativity. As a minimal nontrivial example, a four-qubit pure state has three-qubit mixed reductions; its complete characterization requires six bipartite, eight tripartite, and four quadripartite measures, with the third-order negativity serving as a key separability criterion. We further generalize these separability criteria to multipartite qudit systems and discuss an application to conformal field theory.