Pinching-antenna systems (PASSs) are a recent flexible-antenna technology that is realized by attaching simple components, referred to as pinching elements, to dielectric waveguides. This work explores the potential of deploying PASS for uplink and downlink transmission in multiuser MIMO settings. For downlink PASS-aided communication, we formulate the optimal hybrid beamforming, in which the digital precoding matrix at the access point and the location of pinching elements on the waveguides are jointly optimized to maximize the achievable weighted sum-rate. Invoking fractional programming and Gauss-Seidel approach, we propose two low-complexity algorithms to iteratively update the precoding matrix and activated locations of the pinching elements. We further study uplink transmission aided by a PASS, where an iterative scheme is designed to address the underlying hybrid multiuser detection problem. We validate the proposed schemes through extensive numerical experiments. The results demonstrate that using a PASS, the throughput in both uplink and downlink is boosted significantly as compared with baseline MIMO architectures, such as massive MIMO~and classical hybrid analog-digital designs. This highlights the great potential of PASSs, making it a promising reconfigurable antenna technology for next-generation wireless systems.