Recently, Doröz et al. (2017) proposed a new hard problem, called the finite field isomorphism problem, and constructed a fully homomorphic encryption scheme based on this problem. In this paper, we generalize the problem to the case of Galois rings, resulting in the Galois ring isomorphism problem. The generalization is achieved by lifting the isomorphism between the corresponding residue fields. As a result, this generalization allows us to construct cryptographic primitives over the ring of integers modulo a prime power, instead of a large prime number.