We study the connection between mixing properties for bipartite graphs and materialization of the mutual information in one-shot settings. We show that mixing properties of a graph imply impossibility to extract the mutual information shared by the ends of an edge randomly sampled in the graph. We apply these impossibility results to some questions motivated by information-theoretic cryptography. In particular, we show that communication complexity of a secret key agreement in one-shot setting is inherently uneven: for some inputs, almost all communication complexity inevitably falls on only one party.