In this paper, we propose a new class of nonbinary polar codes with two-stage polarization for ultra-reliable and low-latency communications (URLLC), where the outer (symbol-level) polarization is achieved by using a 2X2 q-ary matrix [1 0; β1] as the kernel and the inner (bit-level) polarization is achieved by a binary polarization matrix for each input symbol. With the two-stage polarization, bit-level code construction is introduced, resulting in partially-frozen symbols, where the frozen bits in these symbols can be used as active-check bits to facilitate the decoder. The encoder/decoder of the proposed codes has the same structure as the original binary polar codes, admitting an easily configurable and flexible implementation, which is an obvious advantage over the existing nonbinary polar codes based on Reed-Solomon (RS) codes. To support high spectral efficiency in URLLC, we also present, in addition to the single level coded modulation scheme with field matched modulation order, a mixed multilevel coded modulation scheme with arbitrary modulation order to trade off the latency against complexity. Simulation results show that our proposed nonbinary polar codes exhibit comparable performance with the RS4-based polar codes and outperform binary polar codes with low decoding latency, suggesting a potential application for 5G URLLC.