A key challenge of massive MTC (mMTC), is the joint detection of device activity and decoding of data. The sparse characteristics of mMTC makes compressed sensing (CS) approaches a promising solution to the device detection problem. However, utilizing CS-based approaches for device detection along with channel estimation, and using the acquired estimates for coherent data transmission is suboptimal, especially when the goal is to convey only a few bits of data. First, we focus on the coherent transmission and demonstrate that it is possible to obtain more accurate channel state information by combining conventional estimators with CS-based techniques. Moreover, we illustrate that even simple power control techniques can enhance the device detection performance in mMTC setups. Second, we devise a new non-coherent transmission scheme for mMTC and specifically for grant-free random access. We design an algorithm that jointly detects device activity along with embedded information bits. The approach leverages elements from the approximate message passing (AMP) algorithm, and exploits the structured sparsity introduced by the non-coherent transmission scheme. Our analysis reveals that the proposed approach has superior performance compared to application of the original AMP approach.