In this paper, we propose a multi-layer artificial neural network (ANN) that is trained with the Levenberg-Marquardt algorithm for use in signal detection over multiple-input multiple-output orthogonal frequency-division multiplexing (MIMO-OFDM) systems, particularly those with low-resolution analog-to-digital converters (LR-ADCs). We consider a blind detection scheme where data symbol estimation is carried out without knowing the channel state information at the receiver (CSIR)---in contrast to classical algorithms. The main power of the proposed ANN-based detector (ANND) lies in its versatile use with any modulation scheme, blindly, yet without a change in its structure. We compare by simulations this new receiver with conventional ones, namely, the maximum likelihood (ML), minimum mean square error (MMSE), and zero-forcing (ZF), in terms of symbol error rate (SER) performance. Results suggest that ANND approaches ML at much lower complexity, outperforms ZF over the entire range of assessed signal-to-noise ratio (SNR) values, and so does it also, though, with the MMSE over different SNR ranges.