One-way functions are fundamental to classical cryptography and their existence remains a longstanding problem in computational complexity theory. Recently, a provable quantum one-way function has been identified, which maintains its one-wayness even with unlimited computational resources. Here, we extend the mathematical definition of functions to construct a generalized one-way function by virtually measuring the qubit of provable quantum one-way function and randomly assigning the corresponding measurement outcomes with identical probability. Remarkably, using this generalized one-way function, we have developed an unconditionally secure key distribution protocol based solely on classical data processing, which can then utilized for secure encryption and signature. Our work highlights the importance of information in characterizing quantum systems and the physical significance of the density matrix. We demonstrate that probability theory and randomness are effective tools for countering adversaries with unlimited computational capabilities.