Randomness extraction against side information is the art of distilling from a given source a key which is almost uniform conditioned on the side information. This paper provides randomness extraction against quantum side information whose extractable key length is given by a quantum generalization of the collision entropy, which is smoothed and conditioned differently from how this is done in existing schemes. Based on the fact that the collision entropy is not subadditive, its optimization with respect to additional side information is introduced, and is shown to be asymptotically optimal. The lower bound derived there for general states is expressed as the difference between two unconditional entropies and its evaluation reduces to an eigenvalue problem of two states, which are the entire state and the marginal state of side information.