Modern e-commerce platforms offer vast product selections, making it difficult for customers to find items that they like and that are relevant to their current session intent. This is why it is key for e-commerce platforms to have near real-time scalable and adaptable personalized ranking and search systems. While numerous methods exist in the scientific literature for building such systems, many are unsuitable for large-scale industrial use due to complexity and performance limitations. Consequently, industrial ranking systems often resort to computationally efficient yet simplistic retrieval or candidate generation approaches, which overlook near real-time and heterogeneous customer signals, which results in a less personalized and relevant experience. Moreover, related customer experiences are served by completely different systems, which increases complexity, maintenance, and inconsistent experiences. In this paper, we present a personalized, adaptable near real-time ranking platform that is reusable across various use cases, such as browsing and search, and that is able to cater to millions of items and customers under heavy load (thousands of requests per second). We employ transformer-based models through different ranking layers which can learn complex behavior patterns directly from customer action sequences while being able to incorporate temporal (e.g. in-session) and contextual information. We validate our system through a series of comprehensive offline and online real-world experiments at a large online e-commerce platform, and we demonstrate its superiority when compared to existing systems, both in terms of customer experience as well as in net revenue. Finally, we share the lessons learned from building a comprehensive, modern ranking platform for use in a large-scale e-commerce environment.