We stand at the foot of a significant inflection in the trajectory of scientific discovery. As society continues on its fast-paced digital transformation, so does humankind's collective scientific knowledge and discourse. We now read and write papers in digitized form, and a great deal of the formal and informal processes of science are captured digitally -- including papers, preprints and books, code and datasets, conference presentations, and interactions in social networks and collaboration and communication platforms. The transition has led to the creation and growth of a tremendous amount of information -- much of which is available for public access -- opening exciting opportunities for computational models and systems that analyze and harness it. In parallel, exponential growth in data processing power has fueled remarkable advances in artificial intelligence, including large neural language models capable of learning powerful representations from unstructured text. Dramatic changes in scientific communication -- such as the advent of the first scientific journal in the 17th century -- have historically catalyzed revolutions in scientific thought. The confluence of societal and computational trends suggests that computer science is poised to ignite a revolution in the scientific process itself.