Generative Retrieval (GR) is rapidly transforming e-commerce search by replacing traditional multi-stage pipelines with the autoregressive decoding of structured Semantic IDs (SIDs). Despite this architectural efficiency, aligning GR models with nuanced, real-world user preferences remains a critical challenge. While Direct Preference Optimization (DPO) offers an efficient alignment solution, its direct application to structured SIDs suffers from three limitations: (i) it penalizes shared hierarchical prefixes, causing gradient conflicts; (ii) it is vulnerable to noisy pseudo-negatives from implicit feedback; and (iii) in multi-label queries with multiple relevant items, it exacerbates a probability "squeezing effect" among valid candidates. To address these issues, we propose RAD-DPO, which introduces token-level gradient detachment to protect prefix structures, similarity-based dynamic reward weighting to mitigate label noise, and a multi-label global contrastive objective integrated with global SFT loss to explicitly expand positive coverage. Extensive offline evaluations and large-scale online A/B testing on JD.com's core search engine demonstrate that RAD-DPO achieves significant improvements in both retrieval precision and training efficiency, proving its robustness for massive industrial deployments.