We introduce random adversarial training (RAT), a novel framework successfully applied to biomedical information extraction (BioIE) tasks. Building on PubMedBERT as the foundational architecture, our study first validates the effectiveness of conventional adversarial training in enhancing pre-trained language models' performance on BioIE tasks. While adversarial training yields significant improvements across various performance metrics, it also introduces considerable computational overhead. To address this limitation, we propose RAT as an efficiency solution for biomedical information extraction. This framework strategically integrates random sampling mechanisms with adversarial training principles, achieving dual objectives: enhanced model generalization and robustness while significantly reducing computational costs. Through comprehensive evaluations, RAT demonstrates superior performance compared to baseline models in BioIE tasks. The results highlight RAT's potential as a transformative framework for biomedical natural language processing, offering a balanced solution to the model performance and computational efficiency.