Different ontologies with conflicting and overlapping concepts cause havoc in the design, develop, and deploy of ontology-driven applications. In this work, we propose a comprehensive ontology interoperability framework for industrial-scale ontology-driven applications. The framework employs three state-of-the-art semantic techniques in different phases of the ontology engineering (OE) life cycle: ontology design patterns (ODPs) in the design phase, ontology matching and versioning (OM\&OV) in the develop phase, and ontology validation (OVA) in the deploy phase, to achieve better ontology interoperability.