Lifelong user modeling, which leverages users' long-term behavior sequences for CTR prediction, has been widely applied in personalized services. Existing methods generally adopted a two-stage "retrieval-refinement" strategy to balance effectiveness and efficiency. However, they still suffer from (i) noisy retrieval due to skewed data distribution and (ii) lack of semantic understanding in refinement. While semantic enhancement, e.g., LLMs modeling or semantic embeddings, offers potential solutions to these two challenges, these approaches face impractical inference costs or insufficient representation granularity. Obsorbing multi-granularity and lightness merits of semantic identity (SID), we propose a novel paradigm that equips retrieval and refinement in Lifelong User Modeling with SEmantic IDs (R2LED) to address these issues. First, we introduce a Multi-route Mixed Retrieval for the retrieval stage. On the one hand, it captures users' interests from various granularities by several parallel recall routes. On the other hand, a mixed retrieval mechanism is proposed to efficiently retrieve candidates from both collaborative and semantic views, reducing noise. Then, for refinement, we design a Bi-level Fusion Refinement, including a target-aware cross-attention for route-level fusion and a gate mechanism for SID-level fusion. It can bridge the gap between semantic and collaborative spaces, exerting the merits of SID. The comprehensive experimental results on two public datasets demonstrate the superiority of our method in both performance and efficiency. To facilitate the reproduction, we have released the code online https://github.com/abananbao/R2LED.