Multiple Sclerosis (MS) is a severely disabling condition that leads to various neurological symptoms. A Brain-Computer Interface (BCI) may substitute some lost function; however, there is a lack of BCI research in people with MS. To progress this research area effectively and efficiently, we aimed to evaluate user needs and assess the feasibility and user-centric requirements of a BCI for people with MS. We conducted an online survey of 34 people with MS to qualitatively assess user preferences and establish the initial steps of user-centred design. The survey aimed to understand their interest and preferences in BCI and bionic applications. We demonstrated widespread interest for BCI applications in all stages of MS, with a preference for a non-invasive (n = 12) or minimally invasive (n = 15) BCI over carer assistance (n = 6). Qualitative assessment indicated that this preference was not influenced by level of independence. Additionally, strong interest was noted in bionic technology for sensory and autonomic functions. Considering the potential to enhance independence and quality of life for people living with MS, the results emphasise the importance of user-centred design for future advancement of BCIs that account for the unique pathological changes associated with MS.