Text response generation for multimodal task-oriented dialog systems, which aims to generate the proper text response given the multimodal context, is an essential yet challenging task. Although existing efforts have achieved compelling success, they still suffer from two pivotal limitations: 1) overlook the benefit of generative pre-training, and 2) ignore the textual context related knowledge. To address these limitations, we propose a novel dual knowledge-enhanced generative pretrained language model for multimodal task-oriented dialog systems (DKMD), consisting of three key components: dual knowledge selection, dual knowledge-enhanced context learning, and knowledge-enhanced response generation. To be specific, the dual knowledge selection component aims to select the related knowledge according to both textual and visual modalities of the given context. Thereafter, the dual knowledge-enhanced context learning component targets seamlessly integrating the selected knowledge into the multimodal context learning from both global and local perspectives, where the cross-modal semantic relation is also explored. Moreover, the knowledge-enhanced response generation component comprises a revised BART decoder, where an additional dot-product knowledge-decoder attention sub-layer is introduced for explicitly utilizing the knowledge to advance the text response generation. Extensive experiments on a public dataset verify the superiority of the proposed DKMD over state-of-the-art competitors.