This study investigates factors influencing employees' perceptions of the usefulness of Business Process Management Systems (BPMS) in commercial settings. It explores the roles of system dependency, system quality, and the quality of information and knowledge in the adoption and use of BPMS. Data were collected using a structured questionnaire from end-users in various firms and analyzed with Partial Least Squares (PLS). The survey evaluated perceptions of service quality, input quality, system attributes, and overall system quality. The findings indicate that service quality, input quality, and specific system attributes significantly influence perceived system quality, while system dependency and information quality are predictors of perceived usefulness. The results highlight the importance of user training, support, and high-quality information in enhancing satisfaction and BPMS. This research offers empirical evidence on the factors impacting user perceptions and acceptance, emphasizing the need for user-centric approaches in BPMS.