Over-the-air (OTA) emulation of diverse sensing target characteristics in a controlled laboratory environment is pivotal for advancing integrated sensing and communication (ISAC) technology, as it facilitates the non-invasive performance evaluation of ISAC base stations (BSs) across complex scenarios. In this work, a flexible multi-target OTA emulation framework based on a wireless cable method is proposed to evaluate the sensing performance of large-scale ISAC BSs. The core concept leverages an amplitude and phase modulation (APM) network to simultaneously establish wireless cables and simulate target spatial characteristics without consuming additional resources on costly radar target emulators. For the wireless cable method, the condition number increases as the number of antennas scales up, which affects the performance of the wireless cable. Although the wireless cable concept has been established for devices-under-test (DUTs) with a limited number of antenna ports, establishing wireless cables for large-scale DUTs remains an open question in the community. We address this problem by optimizing the OTA probe array configuration based on the theoretical properties of strictly diagonally dominant matrices. Experimental results validate the proposed framework, demonstrating high-isolation wireless cables for a 32-element DUT and an extremely low condition number for a 128-element synthetic array. Furthermore, the OTA emulation of a dynamic dual-drone scenario confirms the method's effectiveness and practicality in reproducing complex sensing environments.