This work presents AEGIS, a novel mixed-signal framework for real-time anomaly detection by examining sensor stream statistics. AEGIS utilizes Kernel Density Estimation (KDE)-based non-parametric density estimation to generate a real-time statistical model of the sensor data stream. The likelihood estimate of the sensor data point can be obtained based on the generated statistical model to detect outliers. We present CMOS Gilbert Gaussian cell-based design to realize Gaussian kernels for KDE. For outlier detection, the decision boundary is defined in terms of kernel standard deviation ($σ_{Kernel}$) and likelihood threshold ($P_{Thres}$). We adopt a sliding window to update the detection model in real-time. We use time-series dataset provided from Yahoo to benchmark the performance of AEGIS. A f1-score higher than 0.87 is achieved by optimizing parameters such as length of the sliding window and decision thresholds which are programmable in AEGIS. Discussed architecture is designed using 45nm technology node and our approach on average consumes $\sim$75 $μ$W power at a sampling rate of 2 MHz while using ten recent inlier samples for density estimation. \textcolor{red}{Full-version of this research has been published at IEEE TVLSI}