Integrating artificial intelligence (AI) into wireless channel modeling requires large, accurate, and physically consistent datasets derived from real measurements. Such datasets are essential for training and validating models that learn spatio-temporal channel behavior across frequencies and environments. NYUSIM, introduced by NYU WIRELESS in 2016, generates realistic spatio-temporal channel data using extensive outdoor and indoor measurements between 28 and 142 GHz. To improve scalability and support 6G research, we migrated the complete NYUSIM framework from MATLAB to Python, and are incorporating new statistical model generation capabilities from extensive field measurements in the new 6G upper mid-band spectrum at 6.75 GHz (FR1(C)) and 16.95 GHz (FR3) [1]. The NYUSIM Python also incorporates a 3D antenna data format, referred to as Ant3D, which is a standardized, full-sphere format for defining canonical, commercial, or measured antenna patterns for any statistical or site-specific ray tracing modeling tool. Migration from MATLAB to Python was rigorously validated through Kolmogorov-Smirnov (K-S) tests, moment analysis, and end-to-end testing with unified randomness control, confirming statistical consistency and reproduction of spatio-temporal channel statistics, including spatial consistency with the open-source MATLAB NYUSIM v4.0 implementation. The NYUSIM Python version is designed to integrate with modern AI workflows and enable large-scale parallel data generation, establishing a robust, verified, and extensible foundation for future AI-enabled channel modeling.