This paper presents an initial investigation into the combination of integrated sensing and communication (ISAC) and massive communication, both of which are largely regarded as key scenarios in sixth-generation (6G) wireless networks. Specifically, we consider a cell-free network comprising a large number of users, multiple targets, and distributed base stations (BSs). In each time slot, a random subset of users becomes active, transmitting pilot signals that can be scattered by the targets before reaching the BSs. Unlike conventional massive random access schemes, where the primary objectives are device activity detection and channel estimation, our framework also enables target localization by leveraging the multipath propagation effects introduced by the targets. However, due to the intricate dependency between user channels and target locations, characterizing the posterior distribution required for minimum mean-square error (MMSE) estimation presents significant computational challenges. To handle this problem, we propose a hybrid message passing-based framework that incorporates multiple approximations to mitigate computational complexity. Numerical results demonstrate that the proposed approach achieves high-accuracy device activity detection, channel estimation, and target localization simultaneously, validating the feasibility of embedding localization functionality into massive communication systems for future 6G networks.