As radar systems will be equipped with thousands of antenna elements and wide bandwidth, the associated costs and power consumption become exceedingly high, and a potential solution is to adopt low-resolution quantization technology, which not only reduces data storage needs but also lowers power and hardware costs. This paper focuses on line spectral estimation and detection (LSE\&D) with few-bit ADCs (typically 1-4 bits) by investigating the signal-to-noise ratio (SNR) loss, establishing a framework to understand the impact of intersinusoidal interference, the bit-depth of the quantizer, and the noise variance on weak signal detection in scenarios involving multiple sinusoids under low-resolution quantization. Additionally, a low-complexity, super-resolution, and constant false alarm rate (CFAR) algorithm, named generalized Newtonized orthogonal matching pursuit (GNOMP), is proposed. Extensive numerical simulations are conducted to validate the theoretical findings, particularly in terms of the detection probability bound. The effectiveness of GNOMP is demonstrated through comparisons with state-of-the-art algorithms, the Cramér Rao bound, and the detection probability bound. Real data acquired by mmWave radar further substantiates the effectiveness of GNOMP in practical applications.