Reliable channel estimation (CE) is fundamental for robust communication in dynamic wireless environments, where models must generalize across varying conditions such as signal-to-noise ratios (SNRs), the number of resource blocks (RBs), and channel profiles. Traditional deep learning (DL)-based methods struggle to generalize effectively across such diverse settings, particularly under multitask and zero-shot scenarios. In this work, we propose MoE-CE, a flexible mixture-of-experts (MoE) framework designed to enhance the generalization capability of DL-based CE methods. MoE-CE provides an appropriate inductive bias by leveraging multiple expert subnetworks, each specialized in distinct channel characteristics, and a learned router that dynamically selects the most relevant experts per input. This architecture enhances model capacity and adaptability without a proportional rise in computational cost while being agnostic to the choice of the backbone model and the learning algorithm. Through extensive experiments on synthetic datasets generated under diverse SNRs, RB numbers, and channel profiles, including multitask and zero-shot evaluations, we demonstrate that MoE-CE consistently outperforms conventional DL approaches, achieving significant performance gains while maintaining efficiency.