High performance computing (HPC) systems make extensive use of high speed electrical interconnects, in routing signals among processing elements, or between processing elements and memory. Increasing bandwidth demands result in high density, parallel I/O exposed to crosstalk due to tightly coupled transmission lines. The crosstalk cancellation signaling concept discussed in this paper utilizes the known, predictable theory of coupled transmission lines to cancel crosstalk from neighboring traces with carefully chosen resistive cross-terminations between them. Through simulation and analysis of practical bus architectures, we explore the merits of crosstalk cancellation which could be used in dense interconnect HPC (or other) applications.