The next generation communication systems are evolving towards an increased flexibility in different aspects. Enhanced flexibility is the key in order to address diverse requirements. This paper presents the significance of adaptive guards considering a windowed-OFDM system which supports a variety of services operating asynchronously under the same network. The windowing approach requires a guard duration to suppress the out-of-band emissions (OOBE), and the guard band is required to handle the adjacent channel interference (ACI) along with the windowing. The guards in both time and frequency domains are optimized with respect to the use case and power offset between the users. To fully exploit and further increase the potential of adaptive guards, an interference-based scheduling algorithm is proposed as well. The results show that the precise design that facilitates such flexibility reduce the guards significantly and boost the spectral efficiency.