In magnetic particle imaging (MPI), simultaneous excitation and signal acquisition leads to direct feedthrough interference. While this interference can be mitigated up to some extent with passive compensation, its time-varying nature necessitates active compensation methods to achieve the sensitivity levels needed for applications such as stem cell tracking. We have recently proposed an active compensation technique for MRI, which uses a vector modulator and a lookup-table-based algorithm for reducing the direct feedthrough in the analog domain. Here, we adapt this technique to MPI, demonstrating a successful recovery of the fundamental frequency and a significant increase in detection sensitivity.