Metasurfaces have drawn significant attentions due to their superior capability in tailoring electromagnetic waves with a wide frequency range, from microwave to visible light. Recently, programmable metasurfaces have demonstrated the ability of manipulating the amplitude or phase of electromagnetic waves in a programmable manner in real time, which renders them especially appealing in the applications of wireless communications. To practically demonstrate the feasibility of programmable metasurfaces in future communication systems, in this paper, we design and realize a novel metasurface-based wireless communication system. By exploiting the dynamically controllable property of programmable metasurface, we firstly introduce the fundamental principle of the metasurface-based wireless communication system design. We then present the design, implementation and experimental evaluation of the proposed metasurface-based wireless communication system with a prototype, which realizes single carrier quadrature phase shift keying (QPSK) transmission over the air. In the developed prototype, the phase of the reflected electromagnetic wave of programmable metasurface is directly manipulated in real time according to the baseband control signal, which achieves 2.048 Mbps data transfer rate with video streaming transmission over the air. Experimental result is provided to compare the performance of the proposed metasurface-based architecture against the conventional one. With the slight increase of the transmit power by 5 dB, the same bit error rate (BER) performance can be achieved as the conventional system in the absence of channel coding. Such a result is encouraging considering that the metasurface-based system has the advantages of low hardware cost and simple structure, thus leading to a promising new architecture for wireless communications.