Wireless signals are integral to modern society, enabling both communication and increasingly, environmental sensing. While various propagation models exist, ranging from empirical methods to full-wave simulations, the phenomenon of electromagnetic diffraction is often treated as a secondary effect or a correction factor. This paper positions diffraction as a fundamentally important and underutilized mechanism that is rich with information about the physical environment. Specifically, diffraction-inducing elements generate distinct signatures that are rich with information about their underlying properties such as their geometries. We then argue that by understanding and exploiting these relationships, diffraction can be harnessed strategically. We introduce a general optimization framework to formalize this concept, illustrating how diffraction can be leveraged for both inverse problems (sensing scene details such as object geometries from measured fields) and design problems (shaping radio frequency (RF) fields for communication objectives by configuring diffracting elements). Focusing primarily on edge diffraction and Keller's Geometrical Theory of Diffraction (GTD), we discuss specific applications in RF sensing for scene understanding and in communications for RF field programming, drawing upon recent work. Overall, this paper lays out a vision for systematically incorporating diffraction into the design and operation of future wireless systems, paving the way for enhanced sensing capabilities and more robust communication strategies.