In this letter, we study an attack that leverages a reconfigurable intelligent surface (RIS) to induce harmful interference toward multiple users in massive multiple-input multiple-output (mMIMO) systems during the data transmission phase. We propose an efficient and flexible weighted-sum projected gradient-based algorithm for the attacker to optimize the RIS reflection coefficients without knowing legitimate user channels. To counter such a threat, we propose two reception strategies. Simulation results demonstrate that our malicious algorithm outperforms baseline strategies while offering adaptability for targeting specific users. At the same time, our results show that our mitigation strategies are effective even if only an imperfect estimate of the cascade RIS channel is available.