The emerging Industrial Internet of Things (IIoT) is driving an ever increasing demand for providing low latency services to massive devices over wireless channels. As a result, how to assure the quality-of-service (QoS) for a large amount of mobile users is becoming a challenging issue in the envisioned sixth-generation (6G) network. In such networks, the delay-optimal wireless access will require a joint channel and queue aware scheduling, whose complexity increases exponentially with the number of users. In this paper, we adopt the mean field approximation to conceive a buffer-aware multi-user diversity or opportunistic access protocol, which serves all backlogged packets of a user if its channel gain is beyond a threshold. A theoretical analysis and numerical results will demonstrate that not only the cross-layer scheduling policy is of low complexity but is also asymptotically optimal for a huge number of devices.