The ever-growing demand for ultra-high data rates, massive connectivity, and joint communication-sensing capabilities in future wireless networks is driving research into sub-terahertz (sub-THz) communications. While these frequency bands offer abundant spectrum, they also pose severe propagation and hardware design challenges, motivating the search for alternative antenna solutions beyond conventional antenna arrays. Leaky-wave antennas (LWAs) have emerged as a promising candidate for sub-THz systems due to their simple feed structure, low fabrication cost, and inherent angle-frequency coupling, which enables frequency-controlled beamsteering with simple hardware. In this article, we review the fundamentals of the LWA technology, highlight their unique properties, and showcase their potential in multi-user wideband sub-THz wireless communications. We present representative studies demonstrating that LWAs can simultaneously support high-rate multi-user communications and accurate localization using only a single antenna element. Finally, several key open challenges are outlined, spanning algorithm design, signal processing, information theory, standardization, and hardware implementation, that need to be addressed to fully harness LWAs as a cost-effective and scalable enabler of next generations of wireless systems.