Several previous works have addressed the inherent trade-off between allocating resources in the power and time domains to pilot and data signals in multiple input multiple output systems over block-fading channels. In particular, when the channel changes rapidly in time, channel aging degrades the performance in terms of spectral efficiency without proper pilot spacing and power control. Despite recognizing non-stationary stochastic processes as more accurate models for time-varying wireless channels, the problem of pilot spacing and power control in multi-antenna systems operating over non-stationary channels is not addressed in the literature. In this paper, we address this gap by introducing a refined first-order autoregressive model that exploits the inherent temporal correlations over non-stationary Rician aging channels. We design a multi-frame structure for data transmission that better reflects the non-stationary fading environment than previously developed single-frame structures. Subsequently, to determine optimal pilot spacing and power control within this multi-frame structure, we develop an optimization framework and an efficient algorithm based on maximizing a deterministic equivalent expression for the spectral efficiency, demonstrating its generality by encompassing previous channel aging results. Our numerical results indicate the efficacy of the proposed method in terms of spectral efficiency gains over the single frame structure.