For a regularized least squares estimation of discrete-valued signals, we propose a Linearly involved Generalized Moreau Enhanced (LiGME) regularizer, as a nonconvex regularizer, of designated isolated minimizers. The proposed regularizer is designed as a Generalized Moreau Enhancement (GME) of the so-called sum-of-absolute-values (SOAV) convex regularizer. Every candidate vector in the discrete-valued set is aimed to be assigned to an isolated local minimizer of the proposed regularizer while the overall convexity of the regularized least squares model is maintained. Moreover, a global minimizer of the proposed model can be approximated iteratively by using a variant of the constrained LiGME (cLiGME) algorithm. To enhance the accuracy of the proposed estimation, we also propose a pair of simple modifications, called respectively an iterative reweighting and a generalized superiorization. Numerical experiments demonstrate the effectiveness of the proposed model and algorithms in a scenario of multiple-input multiple-output (MIMO) signal detection.