Owing to the recent advancements in wearable devices for health care, the importance of BP estimation without cuffs increases. Cuff technologies are inappropriate for continuous BP measurement due to their inconvenient usage, invasive character, necessity of calibration, large size, and inability to perform long-term monitoring. Normally, the algorithm used for cuffless BP prediction employs machine learning models that operate according to the data-driven approach. However, although they show high numerical accuracy, ML models do not provide any interpretability, resulting in poor physiological validity and clinical applicability. We propose a combination of Windkessel and ML models that incorporates the physical aspects into the latter one. It is performed by reformulating Windkessel into a form that will allow employing ML models. The result is a system of ODEs which can be used in the neural network. Thus, the inclusion of physical constraints improves the data-driven approach by making models consistent with physics, understandable, and robust. For illustration, we apply the described technique using a publicly available MIMIC-II database that we obtain from the UCI Machine Learning Repository.