Recent progress in compressive sensing states the importance of exploiting intrinsic structures in sparse signal reconstruction. In this letter, we propose a Markov random field (MRF) prior in conjunction with fast iterative shrinkagethresholding algorithm (FISTA) for image reconstruction. The MRF prior is used to represent the support of sparse signals with clustered nonzero coefficients. The proposed approach is applied to the inverse synthetic aperture radar (ISAR) imaging problem. Simulations and experimental results are provided to demonstrate the performance advantages of this approach in comparison with the standard FISTA and existing MRF-based methods.