In multi-master islanded microgrids, the inverter controllers need to share the signals and to coordinate, in either centralized or distributed way, in order to operate properly and to assure a good functionality of the grid. The central controller is used in centralized strategy. In distributed control, Multi-agent system (MAS) is considered to be a suitable solution for coordination of such system. However the latency and disturbance of the network may disturb the communication from central controller to local controllers or among agents or and negatively influence the grid operation. As a consequence, communication aspects need to be properly addressed during the control design and assessment. In this paper, we propose a holistic approach with co-simulation using Functional Mockup Interface (FMI) standard to validate the microgrid control system taking into account the communication network. A use-case of islanded microgrid frequency secondary control with MAS under consensus algorithm is implemented to demonstrate the impact of communication and to illustrate the proposed holistic approach.