Blind source separation (BSS) methods have been applied to deal with the lack of selectivity of ion-selective electrodes (ISE). In this paper, differently from the standard BSS solutions, which are based on the optimization of a mono-objective cost function associated with a given property of the sought signals, we introduce a novel approach by relying on multi-objective optimization. Numerical experiments with actual data attested that our proposal allows the incorporation of additional information on the interference model and also provides the user a set of solutions from which he/she can select a proper one according to his/her prior knowledge on the problem.