We describe a modulation-domain loss function for deep-learning-based speech enhancement systems. Learnable spectro-temporal receptive fields (STRFs) were adapted to optimize for a speaker identification task. The learned STRFs were then used to calculate a weighted mean-squared error (MSE) in the modulation domain for training a speech enhancement system. Experiments showed that adding the modulation-domain MSE to the MSE in the spectro-temporal domain substantially improved the objective prediction of speech quality and intelligibility for real-time speech enhancement systems without incurring additional computation during inference.