This paper presents a unified AI framework for high-accuracy audio anomaly detection by integrating advanced noise reduction, feature extraction, and machine learning modeling techniques. The approach combines spectral subtraction and adaptive filtering to enhance audio quality, followed by feature extraction using traditional methods like MFCCs and deep embeddings from pre-trained models such as OpenL3. The modeling pipeline incorporates classical models (SVM, Random Forest), deep learning architectures (CNNs), and ensemble methods to boost robustness and accuracy. Evaluated on benchmark datasets including TORGO and LibriSpeech, the proposed framework demonstrates superior performance in precision, recall, and classification of slurred vs. normal speech. This work addresses challenges in noisy environments and real-time applications and provides a scalable solution for audio-based anomaly detection.