Recently, deep neural network (DNN) based time-frequency (T-F) mask estimation has shown remarkable effectiveness for speech enhancement. Typically, a single T-F mask is first estimated based on DNN and then used to mask the spectrogram of noisy speech in an order to suppress the noise. This work proposes a multi-mask fusion method for speech enhancement. It simultaneously estimates two complementary masks, e.g., ideal ratio mask (IRM) and target binary mask (TBM), and then fuse them to obtain a refined mask for speech enhancement. The advantage of the new method is twofold. First, simultaneously estimating multiple complementary masks brings benefit endowed by multi-target learning. Second, multi-mask fusion can exploit the complementarity of multiple masks to boost the performance of speech enhancement. Experimental results show that the proposed method can achieve significant PESQ improvement and reduce the recognition error rate of back-end over traditional masking-based methods. Code is available at https://github.com/lc-zhou/mask-fusion.