A method of interpolating the acoustic transfer function (ATF) between regions that takes into account both the physical properties of the ATF and the directionality of region configurations is proposed. Most spatial ATF interpolation methods are limited to estimation in the region of receivers. A kernel method for region-to-region ATF interpolation makes it possible to estimate the ATFs for both source and receiver regions from a discrete set of ATF measurements. We newly formulate the reproducing kernel Hilbert space and associated kernel function incorporating directional weight to enhance the interpolation accuracy. We also investigate hyperparameter optimization methods for this kernel function. Numerical experiments indicate that the proposed method outperforms the method without the use of directional weighting.