Speech self-supervised learning (SSL) represents has achieved state-of-the-art (SOTA) performance in multiple downstream tasks. However, its application in speech enhancement (SE) tasks remains immature, offering opportunities for improvement. In this study, we introduce a novel cross-domain feature fusion and multi-attention speech enhancement network, termed BSS-CFFMA, which leverages self-supervised embeddings. BSS-CFFMA comprises a multi-scale cross-domain feature fusion (MSCFF) block and a residual hybrid multi-attention (RHMA) block. The MSCFF block effectively integrates cross-domain features, facilitating the extraction of rich acoustic information. The RHMA block, serving as the primary enhancement module, utilizes three distinct attention modules to capture diverse attention representations and estimate high-quality speech signals. We evaluate the performance of the BSS-CFFMA model through comparative and ablation studies on the VoiceBank-DEMAND dataset, achieving SOTA results. Furthermore, we select three types of data from the WHAMR! dataset, a collection specifically designed for speech enhancement tasks, to assess the capabilities of BSS-CFFMA in tasks such as denoising only, dereverberation only, and simultaneous denoising and dereverberation. This study marks the first attempt to explore the effectiveness of self-supervised embedding-based speech enhancement methods in complex tasks encompassing dereverberation and simultaneous denoising and dereverberation. The demo implementation of BSS-CFFMA is available online\footnote[2]{https://github.com/AlimMat/BSS-CFFMA. \label{s1}}.