The Detection and Classification of Acoustic Scenes and Events Challenge Task 4 aims to advance sound event detection (SED) systems in domestic environments by leveraging training data with different supervision uncertainty. Participants are challenged in exploring how to best use training data from different domains and with varying annotation granularity (strong/weak temporal resolution, soft/hard labels), to obtain a robust SED system that can generalize across different scenarios. Crucially, annotation across available training datasets can be inconsistent and hence sound labels of one dataset may be present but not annotated in the other one and vice-versa. As such, systems will have to cope with potentially missing target labels during training. Moreover, as an additional novelty, systems will also be evaluated on labels with different granularity in order to assess their robustness for different applications. To lower the entry barrier for participants, we developed an updated baseline system with several caveats to address these aforementioned problems. Results with our baseline system indicate that this research direction is promising and is possible to obtain a stronger SED system by using diverse domain training data with missing labels compared to training a SED system for each domain separately.