In the study of extremes, the presence of asymptotic independence signifies that extreme events across multiple variables are probably less likely to occur together. Although well-understood in a bivariate context, the concept remains relatively unexplored when addressing the nuances of the joint occurrence of extremes in higher dimensions. In this paper, we propose a notion of mutual asymptotic independence to capture the behavior of joint extremes in dimensions larger than two and contrast it with the classical notion of (pairwise) asymptotic independence. Additionally, we define k-wise asymptotic independence, which captures the tail dependence between pairwise and mutual asymptotic independence. The concepts are compared using examples of Archimedean, Gaussian and Marshall-Olkin copulas, among others. Finally, we discuss the implications of these new notions of asymptotic independence on assessing the risk of complex systems under distributional ambiguity.