By transforming identification and control for nonlinear system into optimization problems, a novel optimization method named state transition algorithm (STA) is introduced to solve the problems. In the proposed STA, a solution to a optimization problem is considered as a state, and the updating of a solution equates to a state transition, which makes it easy to understand and convenient to implement. First, the STA is applied to identify the optimal parameters of the estimated system with previously known structure. With the accurate estimated model, an off-line PID controller is then designed optimally by using the STA as well. Experimental results have demonstrated the validity of the methodology, and comparisons to STA with other optimization algorithms have testified that STA is a promising alternative method for system identification and control due to its stronger search ability, faster convergence rate and more stable performance.